H3.3 G34W
GR459/Rabbit/Monoclonal
Gene Bio Solution H3.3 G34W Antibody. Gene Bio Solution’s recombinant rabbit antibody recognizes H3.3 G34W, a variant of the histone H3 protein, which is incorporated into chromatin in a replication-independent manner, often at active genes. Histones are proteins that help package DNA into structures called nucleosomes, playing a key role in gene regulation. H3.3 G34W refers to a specific mutation in the histone H3.3 protein, where the glycine (G) at position 34 is replaced by tryptophan (W). The H3.3 G34W mutation is significant in certain types of cancers, particularly pediatric gliomas and malignant giant cell tumor of bone. Gene Bio Solution’s H3.3 G34W antibody is a mutation-specific immunohistochemical stain against the G34W mutation in histone 3F3A. Nuclear immunoreactivity by the H3.3 G34W antibody supports the diagnosis of giant cell tumor of bone (~95%) and some types of gliomas.
Gene Bio Solution is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.
