The HMB-45 Antibody (Mouse Monoclonal) from GeneBioSolution is a high-quality antibody optimized for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues. HMB-45 is a well-established melanocytic marker that recognizes an epitope of the gp100 glycoprotein, expressed in immature melanosomes. This antibody provides sensitive and specific cytoplasmic staining of melanocytic lesions, with minimal background. It is widely used in diagnostic pathology for the detection of melanomas, metastatic melanomas, and related melanocytic tumors. In particular, HMB-45 helps differentiate melanocytic lesions from other neoplasms, supporting accurate diagnosis. In addition to melanoma, HMB-45 is also a valuable marker in diagnosing angiomyolipoma and perivascular epithelioid cell tumors (PEComas), where gp100 expression is frequently observed. It is typically used in an antibody panel alongside Melan-A, SOX10, and S-100 for comprehensive evaluation of melanocytic tumors. All GeneBioSolution antibodies undergo rigorous validation and quality control, ensuring lot-to-lot consistency, strong staining performance, and reproducible IHC results on both manual and automated staining systems.
Mouse
HMB-45
IgG2a, kappa
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
