The IgG4 Antibody (Rabbit Monoclonal, Clone EP138) from GeneBioSolution is a high-quality antibody optimized for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues). Immunoglobulin G4 (IgG4) is a subclass of IgG with unique structural and functional properties, playing a role in immune tolerance, chronic inflammation, and autoimmune conditions. This antibody provides sensitive and specific cytoplasmic staining of IgG4-positive plasma cells with minimal background. The EP138 clone is widely recognized as a diagnostic marker for IgG4-related disease (IgG4-RD), including conditions such as autoimmune pancreatitis, sclerosing cholangitis, retroperitoneal fibrosis, and inflammatory pseudotumors. In pathology, IgG4 immunohistochemistry is essential for quantifying IgG4-positive plasma cells, which supports the diagnosis of IgG4-RD when correlated with histological features and serum IgG4 levels. In research, IgG4 antibodies are valuable for studying immune regulation, allergy, tolerance, and B-cell biology. All GeneBioSolution antibodies undergo strict validation and quality control, ensuring lot-to-lot consistency, strong staining intensity, and reproducible IHC results on both manual and automated platforms. Clinical & Research Applications Diagnostic marker for IgG4-related disease (IgG4-RD) Evaluation of IgG4-positive plasma cells in tissue sections Research into immune tolerance, chronic inflammation, and autoimmune conditions Studies on immunoglobulin subclass biology and plasma cell disorders
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Colon carcinoma
Nuclear
IgG
Purified human recombinant fusion p21WAF1 protein
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
