IL3RA / CD123 (Acute Myeloid Leukemia Marker)

The IL3RA / CD123 Monoclonal Antibody [Clone IL3RA/1531] specifically detects CD123, the alpha chain of the interleukin-3 receptor (IL3RA), a transmembrane glycoprotein highly expressed on hematopoietic progenitor cells and various hematologic malignancies, including acute myeloid leukemia (AML). Clone IL3RA/1531 demonstrates strong and specific staining of CD123-positive cells and is an essential tool for identifying AML blasts and other CD123-expressing neoplasms in diagnostic and research settings.

Specifications

Species

Mouse

Immunogen

Recombinant fragment of human IL3RA protein (around aa 26-171) (exact sequence is proprietary)

Clone

IL3RA/1531

Isotype

IgG2b / Kappa

Species Reactivity

Human

Positive Control

Lymph Node or Stomach., RPMI-8226 or HDLM-2 cells. Tonsil, THP-1

Specificity

Recognizes CD123, an interleukin 3 specific subunit of a heterodimeric cytokine receptor.

Cellular Localization

Membrane