CD123 is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudo-autosomal region on chromosomes X or Y.
Mouse Monoclonals
Mouse
Hamster, Human, Mouse, Rat
IgG2b / Kappa
IL3RA
Recombinant fragment of human IL3RA protein (around aa 26-171) (exact sequence is proprietary)
IL3RA/1822
Xp22.3 or Yp11.3