INSM1 (MRQ-70) Antibody

INSM1 (MRQ-70) Antibody

The INSM1 (MRQ-70) Rabbit Monoclonal Antibody is a highly sensitive and specific immunohistochemical marker used for the detection of Insulinoma-Associated Protein 1 (INSM1), a zinc-finger transcription factor that plays a critical role in neuroendocrine cell development. This antibody has emerged as a reliable and robust neuroendocrine marker, widely applied in diagnostic pathology for the identification of neuroendocrine tumors (NETs) across multiple tissue types. INSM1 is strongly expressed in a variety of neuroendocrine neoplasms, including small cell lung carcinoma (SCLC), pancreatic neuroendocrine tumors (PanNETs), carcinoid tumors, medullary thyroid carcinoma, and Merkel cell carcinoma. Unlike traditional neuroendocrine markers such as Chromogranin A, Synaptophysin, and CD56, INSM1 offers nuclear staining, providing a clearer and more definitive signal with minimal background. This nuclear localization improves diagnostic accuracy and interpretability in routine formalin-fixed, paraffin-embedded (FFPE) tissue sections. The MRQ-70 clone delivers high specificity, excellent affinity, and consistent performance, making it ideal for clinical diagnostics and research studies. INSM1 is now recommended as part of the core immunohistochemical panel for evaluating suspected neuroendocrine differentiation, particularly in lung and gastrointestinal tumors. Clone: MRQ-70 Host: Rabbit Monoclonal Target: INSM1 (Insulinoma-Associated Protein 1) Applications: Immunohistochemistry (IHC) on FFPE tissues Staining Pattern: Nuclear Species Reactivity: Human Use Cases: Diagnosis of neuroendocrine tumors (SCLC, PanNETs, carcinoids) Differentiation of neuroendocrine from non-neuroendocrine neoplasms Companion marker alongside Chromogranin A, Synaptophysin, and CD56 Research in neuroendocrine tumor biology and development