Fighting Cancer, One Slide at a Time

talk to us

Genebiosolution > IHC Primary Antibody > Involucrin (Squamous Cell Terminal Differentiation Marker)

Involucrin (Squamous Cell Terminal Differentiation Marker)

The Involucrin Monoclonal Antibody [Clone SY5] is a mouse IgG1 antibody that specifically detects human involucrin, a protein essential for the terminal differentiation of squamous epithelial cells. This antibody shows strong cytoplasmic reactivity in the upper layers of stratified squamous epithelium and is validated for use in immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded tissues. Clone SY5 is a reliable tool for distinguishing squamous cell carcinomas, evaluating keratinocyte maturation, and studying epidermal biology.

Datasheet Make Enquiry

Specifications

Species

Mouse

Immunogen

Purified involucrin from human keratinocytes

Clone

SY5

Isotype

IgG1, kappa

Species Reactivity

Human, Gorilla, Owl monkey, Pig, and Dog. Does not react with Mouse. Others not known.

Positive Control

MCF-7 cells. Localized to upper spinous and granular layers in normal skin.

Specificity

This antibody recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this antibody reacts with a 120kDa protein.

Cellular Localization

Cytoplasmic

Ordering Information

Format:

Volume:

Classification
RUO
Catalogue Number
G0166RP

At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.