The Ki-67 antibody [MIB-1] is a monoclonal antibody that targets Ki-67, a nuclear protein associated with cellular proliferation. Ki-67 is expressed during all active phases of the cell cycle (G1, S, G2, and mitosis), but not in resting cells (G0), making it a reliable marker for evaluating the growth fraction of a cell population. The [MIB-1] clone is widely used in immunohistochemistry (IHC) to assess the proliferative activity of tumors, providing important prognostic information in various cancers, including breast, prostate, brain, and lymphoid malignancies. The level of Ki-67 expression, often reported as the Ki-67 labeling index, helps pathologists determine tumor aggressiveness and guide treatment decisions. This antibody is an essential tool in both clinical diagnostics and cancer research for evaluating cell proliferation and tumor behavior.
Mouse
Monoclonal
MIB-1
IgG1
IHC-P
Human
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Nuclear fractions of Hodgkin lymphoma cell lineL248 of human origin.
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