Product Overview
Clone: MKI67/2462
Ki-67 (Proliferating Cell Marker); Clone MKI67/2462 is a monoclonal antibody that specifically detects the Ki-67 antigen, a nuclear protein associated with cellular proliferation. Ki-67 is expressed during all active phases of the cell cycle (G1, S, G2, and M phases) but is absent in resting (G0) cells, making it a widely accepted marker for assessing cell proliferation. Clone MKI67/2462 is optimized for use in immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded tissues, where it provides strong nuclear staining in actively dividing cells. Supplied as a concentrate, this antibody allows for customized protocol development in both research and clinical laboratories. It is commonly used in diagnostic pathology to evaluate tumor growth fraction in various malignancies, including breast, prostate, and lymphoid cancers, aiding in prognosis and treatment planning. Clone MKI67/2462 is a valuable tool for studying cell cycle dynamics and assessing proliferative activity in both normal and diseased tissues.
