The MAGEC2 Antibody (Rabbit Monoclonal, Clone EP405) from GeneBioSolution is a high-quality antibody validated for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues). MAGEC2 (Melanoma Antigen Family C2) is a member of the cancer-testis antigen (CTA) family, normally expressed in germ cells but aberrantly expressed in many malignancies, particularly melanoma and other solid tumors. This antibody provides sensitive and specific nuclear and cytoplasmic staining of MAGEC2, with minimal background. The EP405 clone is widely used in diagnostic and translational research to study tumor immunogenicity, progression, and potential immunotherapy targets. MAGEC2 expression is associated with melanoma, lung carcinoma, breast carcinoma, hepatocellular carcinoma, and sarcomas, making it an important biomarker in tumor pathology and cancer immunology. In addition to oncology, MAGEC2 is a valuable target in cancer vaccine development and immune checkpoint research, given its restricted expression in normal tissues and high prevalence in tumors. All GeneBioSolution antibodies undergo stringent validation and quality control, ensuring lot-to-lot consistency, strong staining performance, and compatibility with both manual and automated IHC staining systems. Clinical & Research Applications Diagnostic and research marker for melanoma and solid tumors Evaluation of cancer-testis antigen expression in malignancies Research into tumor immunology, immune checkpoint pathways, and cancer vaccines Potential biomarker for tumor progression and therapeutic targeting
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Colon carcinoma
Nuclear
IgG
Purified His-tagged MGMT protein
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
