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Genebiosolution > IHC Primary Antibody > Microphthalmia Transcription Factor

Product Overview

Clone: MITF/915

Microphthalmia Transcription Factor (MITF) is a nuclear protein that plays a critical role in the development, function, and survival of melanocytes, as well as in the regulation of genes involved in pigment production. It is widely used as a sensitive and specific marker for melanocytic differentiation in diagnostic pathology. The Clone MITF/915 is a mouse monoclonal antibody provided as a concentrate, optimized for immunohistochemical detection in formalin-fixed, paraffin-embedded tissues. This antibody produces strong nuclear staining in melanocytes and melanoma cells, making it particularly useful for identifying melanocytic tumors, including amelanotic and metastatic melanomas. Its high specificity and consistent nuclear localization make Clone MITF/915 a valuable tool in the differential diagnosis of melanocytic lesions and tumor classification.

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Specifications

Species

Mouse

Immunogen

Recombinant human MITF protein

Clone

MITF/915

Isotype

IgG1, kappa

Species Reactivity

Human and Dog. Does not react with Mouse and Rat. Others not tested.

Positive Control

Jurkat, A-431, HeLa or 501 Mel human melanoma cells or Melanoma.

Specificity

Anti-MITF recognizes a nuclear protein, which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes, benign nevi, and dysplastic nevi.

Cellular Localization

Nuclear

Ordering Information

Format:

Volume:

Classification
RUO
Catalogue Number
G0208RP

At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.