MTAP (Tumor Suppressor Marker)

Product Overview

MTAP (Methylthioadenosine Phosphorylase) antibody, clone MSVA-741R, is a rabbit monoclonal antibody designed to detect the MTAP protein, a key enzyme involved in the salvage pathway of adenine and methionine metabolism. MTAP is ubiquitously expressed in normal tissues but is frequently deleted in a variety of cancers, often in conjunction with the CDKN2A tumor suppressor gene due to their close proximity on chromosome 9p21. Loss of MTAP expression serves as an important diagnostic and prognostic marker, particularly in gliomas, mesotheliomas, and pancreatic carcinomas. The MSVA-741R clone offers high specificity and sensitivity in immunohistochemistry (IHC), producing distinct cytoplasmic staining in MTAP-expressing cells. This makes it a valuable tool for identifying tumors with homozygous MTAP deletion and for stratifying patients for therapies targeting MTAP-deficient cancers. Its robust performance in formalin-fixed, paraffin-embedded tissue samples supports its utility in both clinical and research settings for evaluating tumor suppressor gene status.