MUC-1 Antibody (Rabbit Monoclonal)

MUC-1 Antibody

The MUC1 Antibody (Rabbit Monoclonal, Clone EP85) from GeneBioSolution is a premium-quality antibody optimized for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues). Mucin-1 (MUC1) is a transmembrane glycoprotein expressed on the apical surface of glandular epithelial cells, where it plays a protective role in mucosal barriers. In carcinomas, MUC1 is frequently overexpressed, aberrantly glycosylated, and redistributed, making it a critical biomarker for breast, ovarian, pancreatic, and other epithelial cancers. The EP85 clone delivers sensitive and specific membranous and cytoplasmic staining of MUC1, with minimal background. It is widely used in diagnostic pathology to detect breast carcinoma and its metastases, as well as ovarian, lung, and gastrointestinal carcinomas. MUC1 overexpression has been associated with tumor progression, invasion, metastasis, and poor prognosis, supporting its value as both a diagnostic and prognostic marker. In addition to diagnostic use, MUC1 is an important target in cancer immunology and therapeutic development, including monoclonal antibody therapies and cancer vaccines. Researchers frequently use this antibody to study epithelial tumorigenesis, mucin biology, and tumor-immune interactions. All GeneBioSolution antibodies undergo stringent validation and quality control, ensuring lot-to-lot consistency, strong reproducible staining, and compatibility with both manual and automated IHC staining systems.