MUC-4 Antibody (Rabbit Monoclonal)

MUC-4 Antibody

The MUC4 Antibody (Rabbit Monoclonal, Clone EP256) from GeneBioSolution is a high-affinity antibody optimized for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues). Mucin-4 (MUC4) is a transmembrane glycoprotein involved in epithelial protection, cell signaling, and tumor progression, normally expressed at low levels in healthy tissues but frequently overexpressed in carcinomas. The EP256 clone provides sensitive and specific membranous and cytoplasmic staining of MUC4 with minimal background. It is widely used in diagnostic pathology for identifying pancreatic adenocarcinoma, breast carcinoma, ovarian carcinoma, and gastrointestinal tumors. Overexpression of MUC4 is often associated with aggressive tumor behavior, poor prognosis, and therapeutic resistance, making this antibody a valuable biomarker in both diagnostics and prognostics. In research, MUC4 serves as an important marker for studying cancer biology, mucin regulation, metastasis, and targeted therapy development, as well as its role in tumor-immune interactions and therapeutic resistance. All GeneBioSolution antibodies undergo rigorous validation and quality control, ensuring lot-to-lot consistency, strong reproducible staining, and compatibility with manual and automated IHC staining platforms. Clinical & Research Applications Diagnostic marker for pancreatic, breast, ovarian, and gastrointestinal carcinomas Prognostic indicator in aggressive epithelial tumors Differentiation of mucinous vs non-mucinous tumors Research into cancer progression, metastasis, and mucin-targeted therapies