Product Overview
GM89/Mouse/Monoclonal
GeneBio’s recombinant mouse monoclonal antibody recognizes MUC-6. The MUC-6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 (MUC-6) expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 (MUC-6) has an altered expression. In normal stomach, Mucin 6 (MUC-6) is associated with Lewis type 2; Mucin 6 (MUC-6) is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 (MUC-6) is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.
