Product Overview
Clone: 139H2
MUC1, also known as EMA (Epithelial Membrane Antigen) or CD227, is a high molecular weight transmembrane glycoprotein expressed on the apical surface of most glandular and ductal epithelial cells. It plays a role in cell signaling, adhesion, and immune modulation, and is commonly overexpressed or aberrantly glycosylated in a variety of epithelial cancers, including breast, ovarian, pancreatic, and lung carcinomas. The Clone 139H2 is a mouse monoclonal antibody provided as a concentrate, specifically developed for immunohistochemical detection of MUC1 in formalin-fixed, paraffin-embedded tissue sections. This antibody provides strong membranous and cytoplasmic staining in epithelial cells, making it a reliable marker for identifying epithelial origin in tumors. Its broad reactivity and diagnostic utility make Clone 139H2 a valuable tool in surgical pathology for tumor classification and differential diagnosis.
