The MUM1 Antibody (Rabbit Monoclonal, Clone EP190) from GeneBioSolution is a high-performance antibody validated for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues). MUM1 (Multiple Myeloma Oncogene 1), also known as IRF4, is a transcription factor critical for B-cell differentiation, plasma cell maturation, and immune regulation. The EP190 clone delivers sensitive and specific nuclear staining of MUM1, with minimal background. It is widely used in hematopathology as a diagnostic marker for multiple myeloma, plasma cell neoplasms, diffuse large B-cell lymphoma (DLBCL), and Hodgkin lymphoma. MUM1 is also essential in lymphoma subtyping, where it is applied in panels with CD10 and BCL6 to distinguish germinal center B-cell–like (GCB) from non-GCB DLBCL subtypes. Beyond diagnostic use, MUM1/IRF4 plays an important role in cancer biology and immune regulation research, serving as a marker of late-stage B-cell differentiation and transcriptional control in lymphoid malignancies. All GeneBioSolution antibodies undergo rigorous validation and quality control, ensuring lot-to-lot consistency, strong nuclear staining, and reproducible IHC performance on both manual and automated platforms. Clinical & Research Applications Diagnostic marker for multiple myeloma, plasma cell neoplasms, DLBCL, and Hodgkin lymphoma Subtyping of lymphomas (GCB vs non-GCB DLBCL) Research on B-cell differentiation, transcriptional regulation, and immune response Studies on oncogenesis and plasma cell biology
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Colon carcinoma
Nuclear
IgG1 /κ
BALB/C mice were injected with recombinant human MSH2 protein
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
