MUM1

MUM1

GeneBio’s rabbit recombinant antibody recognizes MUM1/IRF4 (Inteferon Regulatory Factor 4), a nuclear transcription factor necessary for developing and activating B lymphocytes. MUM1 belongs to the IRF gene family containing at least 10 widely expressed genes with similar DNA binding motifs, all involved in the regulation of cell growth, transformation and induction of apoptosis, and development of T-cell immune response. MUM1+ cells are mainly located in the light zone of the germinal center but the highly proliferating, follicle colonizing B blasts of the dark zone fail to express the MUM1 protein. MUM1 expression may denote the final step of intragerminal center B cell differentiation as well as subsequent steps of B cell maturation toward plasma cells. Loss of MUM1 function results in the absence of activated lymphoid cells and Ig secreting plasma cells.