GeneBio’s recombinant mouse antibody recognizes Myeloperoxidase (MPO), an important enzyme used by granulocytes during phagocytic lysis of foreign particles engulfed. In normal tissues and in a variety of myeloproliferative disorders myeloid cells of both neutrophilic and eosinophilic types, at all stages of maturation, exhibit strong cytoplasmic reactivity for Myeloperoxidase (MPO). Erythroid precursors, megakaryocytes, lymphoid cells, mast cells, and plasma cells are nonreactive to Myeloperoxidase (MPO). Myeloperoxidase (MPO) is not observed in the neoplastic cells of a wide variety of epithelial tumors and sarcomas. Myeloperoxidase (MPO) is useful in differentiating between myeloid and lymphoid leukemias.
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Spleen
Cytoplasmic
IgG2b/κ
Recombinant fragment (around aa150-250) of human MPO protein