The MyoD1 Antibody from GeneBioSolution is a high-quality antibody optimized for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues). MyoD1 is a nuclear transcription factor belonging to the myogenic regulatory protein family, essential for skeletal muscle differentiation and development. This antibody provides sensitive and specific nuclear staining of MyoD1 in tumor and muscle tissues, with minimal background. It is widely used in diagnostic pathology as a rhabdomyosarcoma marker, particularly for confirming embryonal and alveolar rhabdomyosarcoma, while showing limited or no reactivity in non-skeletal muscle tumors. In diagnostic practice, MyoD1 is often employed alongside Desmin, Myogenin, and Myoglobin in IHC panels to confirm skeletal muscle lineage. Its high sensitivity and specificity make it a reliable biomarker for differentiating rhabdomyosarcoma from morphologically similar soft tissue tumors. Beyond pathology, MyoD1 is an important marker in muscle biology research, supporting studies on myogenesis, muscle regeneration, and transcriptional regulation in muscle cells. All GeneBioSolution antibodies undergo rigorous validation and quality control, ensuring lot-to-lot consistency, strong nuclear staining, and reproducible results across manual and automated IHC systems.
Rabbit
Recombinant mouse MyoD1 protein
5.8A
IgG1, kappa
Human, Mouse, Rat, and Chicken. Others not known.
Rhabdomyosarcoma
Recognizes a phosphor-protein of 45kDa, identified as MyoD1. The epitope of this antibody maps between amino acids 180-189 in the C-terminal region of the mouse MyoD1 protein.
Nucleus
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
