The Myogenin Mouse Monoclonal Antibody [Clone F5D] is a well-characterized antibody for the specific nuclear detection of myogenin, a critical transcription factor in skeletal muscle development and differentiation. It is widely used as a sensitive and specific immunohistochemical marker for identifying rhabdomyosarcomas, particularly alveolar and embryonal subtypes. This antibody is ideal for use on formalin-fixed, paraffin-embedded (FFPE) tissues and provides crisp nuclear staining in tumor cells of skeletal muscle origin.
Mouse
Rat myogenin peptide (aa 73-94) followed by rat myogenin recombinant fragment (aa 30-224) (Epitope aa 138-158)
F5D
IgG1, kappa
Human, Mouse, Rat, Dog, Cat, and Pig. Others not known.
Rh-30 cells. Skeletal muscle or rhabdomyosarcoma.
Anti-myogenin labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilms' tumor.
Nuclear