Myoglobin (clone GR69) is a mouse monoclonal antibody specifically developed to detect myoglobin, a small, oxygen-binding heme protein predominantly expressed in cardiac and skeletal muscle tissues. This antibody targets a well-defined epitope on the myoglobin molecule, allowing for sensitive and specific immunohistochemical identification of muscle-derived cells. Myoglobin plays a key physiological role in oxygen storage and transport within muscle fibers, and its presence is a reliable marker for muscle differentiation. The GR69 clone is widely used in diagnostic pathology to confirm the muscle origin of neoplasms, particularly in distinguishing rhabdomyosarcomas from other small round cell tumors. It is also valuable in forensic and clinical pathology for detecting muscle injury or necrosis, as myoglobin can be released into tissues and fluids following trauma. The antibody provides strong cytoplasmic staining, making it an effective tool for both research and diagnostic applications involving muscle tissue characterization.
Rabbit
Recombinant human full-length Myoglobin (MB) protein
GR69
IgG / Kappa
This antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections. No further titration is required.
Human
Skeletal muscle
Cytoplasmic