NKX3.1 Antibody

NKX3.1

The NKX3.1 Antibody from GeneBioSolution is a high-quality antibody validated for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues). NKX3.1 is a prostate-specific homeobox transcription factor that plays a key role in prostate development, differentiation, and tumor suppression. This antibody provides sensitive and specific nuclear staining of NKX3.1 in prostate epithelial cells, with minimal background. In diagnostic pathology, NKX3.1 is a highly specific marker for prostate origin, making it invaluable in confirming primary and metastatic prostate adenocarcinoma, even in small biopsy samples or poorly differentiated tumors. NKX3.1 has greater specificity than PSA in identifying prostate cancer metastases, particularly in lymph nodes, bones, and other secondary sites, and is frequently used alongside markers such as PSA, PSAP, and ERG. In research, NKX3.1 antibodies are applied in studies of prostate cancer biology, tumor progression, metastasis, and transcriptional regulation, as well as its role as a tumor suppressor gene. All GeneBioSolution antibodies undergo rigorous validation and quality control, ensuring lot-to-lot consistency, strong nuclear staining, and reproducible IHC performance across manual and automated staining systems.