The NSE Antibody (Rabbit Monoclonal, Clone EP319) from GeneBioSolution is a high-quality antibody optimized for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues). Neuron-Specific Enolase (NSE) is a glycolytic enzyme expressed in neurons and neuroendocrine cells, serving as a reliable biomarker for neuroendocrine differentiation and tumor pathology. The EP319 clone provides sensitive and specific cytoplasmic staining of NSE with minimal background. It is widely applied in diagnostic pathology for the detection of neuroendocrine tumors, small cell lung carcinoma, pheochromocytoma, and neuroblastoma. NSE expression is a key diagnostic feature in panels for neuroendocrine differentiation, often used alongside markers such as Chromogranin A and Synaptophysin. Beyond diagnostics, NSE is frequently employed in neuroscience and oncology research to study neuronal activity, tumor metabolism, and neuroendocrine signaling pathways. All GeneBioSolution antibodies undergo rigorous validation and quality control, ensuring lot-to-lot consistency, reproducible results, and compatibility with both manual and automated IHC systems. Clinical & Research Applications Diagnostic marker for neuroendocrine tumors and small cell lung carcinoma (SCLC) Identification of neuroblastoma, pheochromocytoma, and other neural crest tumors Marker of neuroendocrine differentiation in tumor pathology Research on neurobiology, tumor metabolism, and glycolytic pathways
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Pancreas or brain
Cytoplasmic
IgG
A synthetic peptide corresponding to aa416-433 of human NSE gamma
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
