Product Overview
Clone: A73-B/D12
Nuclear Mitotic Apparatus Protein (NuMA); Clone A73-B/D12 (Concentrate) is a monoclonal antibody that specifically targets NuMA (Nuclear Mitotic Apparatus protein), a key structural component involved in the organization of the mitotic spindle during cell division and in maintaining nuclear architecture during interphase. NuMA plays a crucial role in spindle pole assembly and chromosome segregation, making it an important marker for studying cell cycle dynamics and mitosis. Clone A73-B/D12 is supplied as a concentrate for flexible use in immunohistochemistry (IHC) and immunocytochemistry (ICC) on formalin-fixed, paraffin-embedded tissues or cultured cells. This antibody exhibits strong nuclear staining in interphase cells and spindle pole staining in mitotic cells, providing a reliable indicator of cell proliferation and mitotic activity. It is widely used in both research and diagnostic pathology to investigate mitotic processes, tumor cell proliferation, and nuclear structure abnormalities, particularly in cancer and other proliferative disorders.
