The OLIG2 Antibody from GeneBioSolution is a high-performance antibody validated for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues). OLIG2 (Oligodendrocyte Transcription Factor 2) is a basic helix-loop-helix (bHLH) transcription factor critical for the development of oligodendrocytes and motor neurons, as well as for the maintenance of neural progenitor cells. This antibody provides sensitive and specific nuclear staining of OLIG2 in glial and neural tissues, with minimal background. It is widely used in diagnostic neuropathology as a marker for gliomas, including oligodendrogliomas, astrocytomas, and glioblastomas, where OLIG2 expression supports classification and tumor grading. OLIG2 has become a recommended biomarker in the WHO classification of CNS tumors, particularly in distinguishing glial tumors from other CNS neoplasms. In research, OLIG2 is an essential marker for studies on neurodevelopment, neural stem/progenitor cells, gliomagenesis, and central nervous system regeneration. It is also employed in investigations into brain tumor biology, transcriptional regulation, and therapeutic resistance mechanisms. All GeneBioSolution antibodies undergo strict validation and quality control, ensuring lot-to-lot consistency, strong nuclear staining, and reproducible IHC results on both manual and automated staining systems.
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Astrocytoma
Nuclear
IgG
Fragment (around aa 200-300) of human Olig2 protein
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
