Product Overview
GR288/Rabbit/Monoclonal
GeneBio’s recombinant rabbit antibody recognizes p21 WAF1, a tumor supressor protein involved in the pathogensis of a variety of cancers. The p21 WAF1 antibody recognizes a 21kDa protein. This p21 WAF1 antibody is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21 is a specific inhibitor of cdk’s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of the p21 gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. p21 expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).
