p53 antibody [DO-7] is a widely used monoclonal antibody that specifically recognizes the human p53 tumor suppressor protein, a critical regulator of the cell cycle and apoptosis. The p53 protein plays a key role in preventing cancer formation by repairing damaged DNA or inducing cell death in cells with severe genetic damage. The DO-7 clone detects both wild-type and mutated forms of p53, making it highly valuable in cancer diagnostics and research. This antibody is frequently employed in immunohistochemistry to evaluate p53 expression in a wide range of human tumors, including breast, colon, lung, and bladder cancers. Overexpression or accumulation of p53, often detected by DO-7, is commonly associated with p53 gene mutations and tumor progression. Due to its high specificity and consistent performance, p53 antibody [DO-7] is a trusted tool for pathologists and researchers in identifying and characterizing p53-related abnormalities in tissue samples.
Mouse
Monoclonal
DO-7
IgG2b
WB, IHC-P, IHC-Fr, FCM,IP
Human, Bovine, Monkey
Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix
Recombinant human wild type p53 protein expressed in E. coli.