Product Overview
Clone: PC10
Proliferating Cell Nuclear Antigen (PCNA), detected by the monoclonal antibody clone PC10, is a key marker of cell proliferation and is strongly associated with the G1 and S phases of the cell cycle. PCNA acts as a co-factor for DNA polymerase delta, playing an essential role in DNA replication and repair by stabilizing the replication complex. The PC10 clone specifically recognizes the PCNA protein with high sensitivity, making it a widely used tool in immunohistochemistry for assessing proliferative activity in both normal and neoplastic tissues. Because PCNA expression correlates with the rate of cell division, it is commonly used in cancer diagnostics and research to evaluate tumor growth and aggressiveness. Under normal physiological conditions, PCNA is primarily localized in the nucleus, where it forms distinct foci during DNA synthesis, reflecting its role in active DNA replication.
