Product Overview
GM357/Mouse/Monoclonal
GeneBio’s recombinant mouse antibody recognizes PD-1/PDCD-1 (programmed cell death-1 protein), designated CD279, a type I transmembrane receptor and a member of the immunoglobin gene superfamily. PD-1/PDCD-1 is expressed on activated T-cells, B-cells, and myeloid cells. The PD-1/PDCD-1 antibody is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PD-1/PDCD-1 is expressed by few B-cells, so the PD-1/PDCD-1 antibody may be a more specific and valuable diagnostic marker in angioimmunoblastic lymphoma. In addition, PD-1/PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.