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Genebiosolution > IHC Primary Antibody > PHH3

Product Overview

Clone: BC37

Histone H3 is a nuclear protein that plays a central role in chromatin structure and gene regulation. During mitosis, phosphorylation at serine 10 (Ser10) is a critical modification that correlates with chromosome condensation and cell division. The phosphorylated form, known as pHH3, is tightly linked to the G2/M phases of the cell cycle. As such, it serves as a precise marker for mitotic figures in tissue sections and is widely used in oncology to assess proliferative activity in tumors. This makes pHH3 a valuable tool in cancer research and pathology.

INTENDED USE

For Research use only (RUO). It is designed for the immunohistochemical detection of phosphorylated Histone H3 (Ser10) in formalin-fixed, paraffin-embedded tissues. It is not approved for diagnostic or therapeutic procedures.

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Specifications

Host Species

Rabbit

Clone

BC37

Isotype

IgG

Immunogen

Human (others not tested)

Buffer

Tris-HCl with stabilizers and <0.1% ProClin

Target Location

Nuclear (Mitotic figures)

SPECIES REACTIVITY

Human

POSITIVE CONTROLS

Tonsil, Melanoma

EPITOPE

Phospho-Ser10 of Histone H3

Ordering Information

Format:

Volume:

Classification
RUO
Catalogue Number
G3130RP

At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.