The PNL2 Antibody (Melanoma Associated Antigen) is a highly specific immunohistochemical marker widely used in the detection and diagnosis of melanocytic lesions, particularly malignant melanoma. PNL2 is a monoclonal antibody that reacts strongly with melanocyte-associated antigens, providing clear cytoplasmic staining in melanoma cells while showing minimal cross-reactivity with non-melanocytic tissues. This makes it an invaluable diagnostic tool for distinguishing melanoma from non-melanocytic tumors and mimickers such as sarcomas and carcinomas. Validated for use on formalin-fixed, paraffin-embedded (FFPE) tissue samples, the PNL2 Antibody demonstrates excellent sensitivity and reproducibility, ensuring consistent results in clinical pathology and research applications. Its high specificity for melanocytic differentiation supports its role as a complementary marker to S100, HMB-45, and Melan-A in comprehensive melanoma panels. Optimized for immunohistochemistry (IHC) and compatible with automated staining platforms, the PNL2 Antibody is essential for pathologists and oncology researchers focused on accurate melanoma diagnosis, tumor classification, and biomarker studies in skin cancer research.
Mouse
Melanocyte antigen
PNL2
IgG1
Human, Mouse and Dog. Others not known.
Melanoma
PNL2 is a novel monoclonal antibody which has recently been introduced as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom.
Cytoplasmic
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