PSA is a kallikrein-like serine protease (33–34 kDa) secreted primarily by the prostate gland. It is found at high levels in seminal fluid and can be measured in blood serum, especially in cases of prostate carcinoma. In serum, PSA typically forms a complex with alpha-1-antichymotrypsin (ACT). The proportion of PSA-ACT complexes is significantly elevated in prostate cancer compared to benign prostatic conditions. Clone 3E6 is well suited for diagnostic research and pairs effectively with complementary antibodies in sandwich assays.
This monoclonal antibody is designed to detect PSA, a secreted glycoprotein expressed by prostatic epithelium. It is highly specific for PSA and suitable for identifying both normal and malignant prostate tissues.
Mouse
Human Prostate Specific Antigen (PSA).
3E6
IgG1, Kappa.
Supplied in PBS with 0.05% BSA and 0.05% sodium azide (also available BSA/azide-free).
Human
Prostate carcinoma or normal prostate tissue, PC12 cells.
Secreted.