PSAP (Prostate Specific Acid Phosphatase)

PSAP (Prostate Specific Acid Phosphatase)

The PSAP (Prostate Specific Acid Phosphatase) Antibody, Clone PASE/4LJ (Mouse Monoclonal) is a highly specific and widely validated marker for immunohistochemistry (IHC) in prostate pathology. PSAP is a lysosomal acid phosphatase expressed almost exclusively in prostatic epithelial cells and secreted into seminal fluid, making it a lineage-specific biomarker of prostatic differentiation. Clone PASE/4LJ demonstrates strong cytoplasmic staining with high specificity in formalin-fixed paraffin-embedded (FFPE) tissues, ensuring reproducible and diagnostic-quality results. Clinically, PSAP immunodetection is indispensable for confirming primary and metastatic prostate adenocarcinoma, especially in cases where PSA expression is reduced or absent. It is particularly useful in poorly differentiated carcinomas and metastatic deposits in lymph nodes, bone, or visceral sites, where establishing prostatic origin is essential for accurate diagnosis and patient management. When combined with other prostate lineage markers such as PSA, Prostein, and NKX3.1, PSAP enhances diagnostic accuracy and supports comprehensive prostate cancer profiling. Beyond diagnostics, PSAP expression has translational significance in studies of androgen-regulated pathways, tumor progression, and prostate cancer metastasis biology. Its restricted expression pattern makes it a reliable marker in both routine pathology and molecular oncology research.