Product Overview
Clone: rATRX/3446
Recombinant ATRX / RAD54 (Alpha Thalassemia Mental Retardation X-linked), Clone rATRX/3446, is a monoclonal antibody specifically developed to detect the ATRX protein, a chromatin remodeling factor involved in gene regulation, DNA repair, and maintaining genomic stability. ATRX plays a critical role in epigenetic regulation, particularly in heterochromatin formation and telomere maintenance. Mutations or loss of ATRX expression have been implicated in various cancers, including gliomas, pancreatic neuroendocrine tumors, and certain sarcomas, as well as in the genetic disorder alpha thalassemia mental retardation syndrome. Clone rATRX/3446 provides specific nuclear staining in cells expressing ATRX and is optimized for immunohistochemical analysis of formalin-fixed, paraffin-embedded tissue sections. This antibody is a valuable tool in both clinical diagnostics and research for assessing ATRX status, aiding in tumor classification, prognosis, and understanding mechanisms of chromatin remodeling and tumorigenesis. Its high specificity and reproducible staining make Clone rATRX/3446 essential for studies involving ATRX-associated diseases.
