Product Overview
Clone: 6E3
Through its modulation of Oct4, SALL4 is necessary for the preservation of embryonic stem cell pluripotency. SALL4 has been shown to be a sensitive and specific marker for ovarian primitive germ-cell tumours and seminomas. Research has shown that high SALL4 staining is present in more than 90% of tumour cells in embryonal carcinomas and intratubular germ-cell neoplasias. Furthermore, all 31 yolk sac tumours (5 paediatric and 26 postpubertal) had tumour cells that were strongly positive for SALL4 labelling but negative for Oct4. Research indicates that SALL4 antibody is a more promising pan germ-cell marker than Oct4 and PLAP antibodies.
