Product Overview
Clone: SMAD4/7906R
DPC4 is a group of evolutionarily conserved proteins that mediate signalling from the ligand-activated membrane receptor serine/threonine kinases to nuclear destinations. TGF-β family receptors phosphorylate SMAD proteins (SMAD1 and SMAD2) when they bind to ligands. After entering the nucleus, these proteins start transcription. The receptor-activated SMAD1 and 2 must associate with the product of deleted in pancreatic cancer, locus 4 (DPC4), also referred to as SMAD4, in order to perform this function. Since SMAD4/DPC4 is inactivated in over half of pancreatic carcinomas and to a lesser amount in a number of other malignancies, it is also implicated as a tumour suppressor. About 80% of instances of pancreatic adenocarcinoma have no SMAD4 expression, while endometrial (0%), colorectal (0%), ovarian (3%), lung (0%), breast (2%) and malignant melanoma (4%), adenocarcinomas, and lung (0%), adenocarcinomas, hardly ever have this. An essential sign for validating a pancreatic cancer diagnosis is SMAD4.
INTENDED USE
For Research Use Only (RUO).
