Somatostatin Receptor Type 2 (SSTR2) Antibody is a high-affinity antibody developed for the specific detection of SSTR2, a G-protein–coupled receptor (GPCR) encoded by the SSTR2 gene. SSTR2 is one of five somatostatin receptor subtypes and plays a central role in mediating the inhibitory effects of somatostatin on hormone secretion, neurotransmission, and cell proliferation. Activation of SSTR2 leads to suppression of adenylate cyclase activity, calcium influx, and downstream signaling pathways critical for endocrine regulation. Clinically, SSTR2 is a well-established diagnostic and therapeutic biomarker in neuroendocrine tumors (NETs), including pancreatic NETs, gastrointestinal carcinoids, and pituitary adenomas. Strong SSTR2 expression is correlated with responsiveness to somatostatin analog therapies (e.g., octreotide, lanreotide) and is the primary molecular target for peptide receptor radionuclide therapy (PRRT), including ^177Lu- and ^68Ga-labeled somatostatin analogs used in theranostic imaging and treatment.
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Neuroendocrine tumor
cell surface
IgG
Recombinant fragment (around aa 169-369) of human SS2R
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