SOX10 Rabbit Monoclonal Antibody is a high-affinity nuclear antibody optimized for immunohistochemistry (IHC) on FFPE tissues to detect SOX10, a neural-crest–lineage transcription factor essential for melanocyte and Schwann-cell differentiation. In routine surgical pathology, SOX10 is among the most reliable markers for melanocytic neoplasms (including desmoplastic melanoma, where cytoplasmic melanocyte markers may be weak/negative) and for peripheral nerve sheath tumors. Compared with broad markers like S100, SOX10 typically yields clean, intense nuclear staining with reduced off-target background, which improves interpretability in highly pigmented or fibrotic lesions. Diagnostic panels frequently pair SOX10 with S100, HMB45, Melan-A/MART-1, and Ki-67 for melanocytic tumors, and with EMA, Claudin-1, and S100 for nerve-sheath differentials; in breast pathology, SOX10 supports workups of triple-negative breast carcinoma where basal/myoepithelial features are suspected.
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Melanoma
Nuclear
IgG
Recombinant human SOX10 protein fragment (around aa 115-269)
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
