Synaptophysin (clone GM208) is a monospecific mouse monoclonal antibody designed for the detection of synaptophysin, a 38 kDa integral membrane glycoprotein predominantly found in presynaptic vesicles of neurons and neuroendocrine cells. This antibody is highly specific and sensitive, making it a valuable tool in both research and diagnostic histopathology for identifying neuronal and neuroendocrine differentiation. Clone GM208 recognizes an epitope on synaptophysin that is well-conserved across species, enabling its use in a variety of animal models as well as human tissue. Commonly utilized in immunohistochemistry (IHC), this antibody is frequently employed in the diagnosis of neuroendocrine tumors, such as pheochromocytomas and carcinoid tumors, where it provides strong, punctate cytoplasmic staining patterns typical of synaptic vesicle proteins. Its robust performance and specificity make Synaptophysin (clone GM208) a reliable marker in neuropathological and oncological applications.
Mouse
Synthetic peptide within Human Synaptophysin aa 200-300
GM208
IgG1/Kappa
This antibody has been pre-titered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections.
Human
Cerebellum or Pheochromocytoma., HeLa or Y79 cells. Pancreas, HePG2, SH-SY-5Y
Cell junction, Cytoplasmic vesicle, Secretory vesicle, Synapse, Synaptic vesicle membrane, Synaptosome
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