TAG-72 (Tumor-Associated Glycoprotein), Clone B72.3 (Concentrate), is a mouse monoclonal antibody specifically designed to detect TAG-72, a high-molecular-weight glycoprotein complex that is overexpressed in a variety of adenocarcinomas, including those of the breast, colon, ovary, pancreas, and lung. The B72.3 clone recognizes a sialylated glycoform of the mucin-like protein and has been widely used in both research and clinical diagnostics due to its high specificity for tumor tissue. Provided in a concentrated format, this antibody allows for customizable dilution and optimization in immunohistochemistry (IHC) protocols. It is particularly valuable in tumor typing, helping to distinguish adenocarcinomas from other malignancies, especially in metastatic settings. TAG-72 is minimally expressed in normal adult tissues, which enhances the diagnostic utility of Clone B72.3 by minimizing background staining. This antibody is a critical tool in cancer diagnostics and research, aiding in tumor identification, characterization, and potential therapeutic targeting.
Mouse
Membrane-enriched fraction of a human breast carcinoma liver metastasis
B72.3
IgG1, kappa
Human, Cow, Dog, Hamster, and Rat. Others not known. Positive Control: Jurkat cells, breast or lung carcinoma.
Recognizes an oncofetal antigen of 220kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. This antibody defines the mucin-carried sialylated-Tn epitope.
This product is not sterile.
Cytoplasmic and cell surface
