TCL1, Clone GM92, is a mouse monoclonal antibody specifically developed to detect T-cell leukemia/lymphoma protein 1 (TCL1), a proto-oncogene that plays a significant role in the regulation of T-cell and B-cell development. TCL1 is notably overexpressed in a variety of hematological malignancies, including T-cell prolymphocytic leukemia (T-PLL), chronic lymphocytic leukemia (CLL), and some types of B-cell lymphomas, making it a valuable diagnostic and prognostic marker in hematopathology. The GM92 clone provides high specificity and consistent staining, ideal for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded tissues. Its mouse monoclonal origin ensures reproducibility and compatibility with standard detection systems. TCL1 is primarily localized in the nucleus and cytoplasm of malignant lymphocytes, and its expression is associated with increased cell survival and proliferation. The GM92 antibody is widely used in clinical and research settings to help classify lymphoid malignancies, investigate disease mechanisms, and potentially guide therapeutic decision-making.
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Tonsil
Cytoplasmic
IgG1 /κ
Recombinant human TCL1 protein fragment (around aa 2-109)
