TdT

Product Overview

ChatGPT said: TdT (Terminal deoxynucleotidyl Transferase), Clone GM51, is a monospecific mouse monoclonal antibody designed to detect TdT, a nuclear enzyme involved in the addition of nucleotides during V(D)J recombination in immature lymphoid cells. This enzyme is a key marker for early lymphoid precursors, and its expression is typically restricted to immature T and B lymphocytes. The GM51 clone offers high specificity and affinity, ensuring precise and reproducible staining, particularly in immunohistochemistry (IHC) applications using formalin-fixed, paraffin-embedded tissue sections. As a diagnostic tool, TdT GM51 is invaluable in identifying lymphoblastic leukemias and lymphomas, such as acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma, aiding in the differentiation from more mature lymphoid or myeloid neoplasms. Its monospecific nature enhances staining accuracy, minimizing background and cross-reactivity. Clinically and in research, GM51 is widely used to characterize hematologic malignancies and monitor minimal residual disease in leukemic conditions.