TdT

Product Overview

TdT (Terminal deoxynucleotidyl Transferase), Clone GR446, is a rabbit monoclonal antibody specifically designed to detect TdT, a nuclear enzyme critical in the early development of lymphoid cells. This enzyme is involved in V(D)J recombination, a process essential for generating diversity in the antigen receptors of T and B cells. The GR446 clone provides high specificity and sensitivity for TdT, making it a powerful tool in immunohistochemistry (IHC), particularly in formalin-fixed, paraffin-embedded tissue samples. Its rabbit monoclonal origin offers advantages such as stronger binding affinity and reduced background staining compared to traditional mouse monoclonal antibodies. TdT expression is a hallmark of immature lymphoid cells, and the GR446 clone is widely used in the diagnosis of acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma, helping to distinguish these malignancies from other hematologic disorders. This antibody is highly valued in both clinical diagnostics and research for its reliability in detecting immature lymphoid populations and assessing disease progression or minimal residual disease.