TFE3, Clone GR365, is a rabbit monoclonal antibody specifically designed to detect Transcription Factor E3 (TFE3), a member of the MiT family of transcription factors involved in cell growth, proliferation, and lysosomal biogenesis. The GR365 clone offers high specificity and strong nuclear staining, making it especially useful in immunohistochemistry (IHC) applications on formalin-fixed, paraffin-embedded tissues. TFE3 is clinically significant as it is commonly overexpressed or abnormally translocated in certain cancers, most notably in Xp11 translocation renal cell carcinomas (RCCs) and alveolar soft part sarcomas (ASPS). Detection of TFE3 expression using the GR365 clone aids in the diagnosis and classification of these tumors, which often exhibit distinct morphological and clinical features. The rabbit monoclonal nature of GR365 provides enhanced sensitivity and minimal background staining, allowing for clear and reliable interpretation. This antibody is a valuable tool in both clinical diagnostics and research settings focused on tumor biology and gene fusion-related oncogenesis.
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Testis (germ cells) or Xp11 translocation renal cell carcinoma
Nuclear
IgG
Recombinant full-length human TFE3 protein
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
