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Genebiosolution > IHC Primary Antibody > Thymidylate Synthase

Thymidylate Synthase

GR245/Rabbit/Monoclonal

The Anti-Thymidylate Synthase (TS) Rabbit Monoclonal Antibody [Clone GR245] is a highly specific and sensitive tool for detecting thymidylate synthase, a critical enzyme involved in DNA synthesis and repair. Thymidylate synthase catalyzes the conversion of deoxyuridylate (dUMP) to deoxythymidylate (dTMP), which is essential for DNA replication and cell proliferation. TS is a key target in cancer chemotherapy, particularly with 5-fluorouracil (5-FU)-based treatments. Overexpression of TS has been associated with resistance to such therapies, making it an important biomarker for prognosis and therapeutic response prediction in colorectal, gastric, and other cancers.

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Specifications

Species Reactivity

Humans; others not tested

Known Applications

Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As

Buffer with protein carrier and preservative

Storage

Store at 2ºC to 8ºC

Control

5-FU resistant cancer

Visualization

Cytoplasmic

Isotype

IgG1

Immunogen

Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary)

Ordering Information

Format:

Volume:

Classification
RUO
Catalogue Number
G2719RP

At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.