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Product Overview

Clone: 8G7G3/1

TTF-1 belongs to the family of homeodomain transcription factors called NKx2. The thyroid gland and lung epithelial cells both express it. The pituitary, prostate, adrenal glands, liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, and testes all have non-reactive nuclei. Anti-TTF-1 is helpful in distinguishing malignant mesothelioma, mediastinal germ cell tumours, and lung primary adenocarcinoma from breast-derived metastases. Additionally, it can be utilised to distinguish lymphoid infiltrates from small cell lung cancer. Loss of TTF-1 expression in non-small cell lung carcinoma has been connected with aggressive behaviour of such neoplasms. Thyroid cancers also exhibit TTF-1 reactivity.

Specifications

SPECIES

Mouse

IMMUNOGEN

Recombinant full-length Rat TTF-1 protein

CLONE

8G7G3/1

ISOTYPE

IgG1, kappa

SPECIFICITY

Identifies thyroid transcription factor 1 (TTF-1) as a 40 kDa protein.

SPECIES REACTIVITY

Human, Mouse, and Rat. Shows a broad species reactivity.

POSITIVE CONTROL

MAD109, MLE-15, H441-4, or H345 cells. Normal thyroid or lung.

CELLULAR LOCALIZATION

Nuclear.

Ordering Information

Format:

Volume:

  • Classification
  • RUO
  • Catalogue Number
  • G00144RP