The Tumor Endothelial Marker 8 (TEM8) / Anthrax Toxin Receptor 1 Mouse Monoclonal Antibody [Clone TEM8/589] is a highly specific antibody that detects TEM8 (ANTXR1), a transmembrane glycoprotein implicated in tumor vasculature, angiogenesis, and cancer progression. TEM8 functions as a receptor for the protective antigen component of anthrax toxin and is overexpressed in the endothelial cells of various tumor types. Clone TEM8/589 is validated for use in formalin-fixed, paraffin-embedded (FFPE) tissues, offering crisp membrane and cytoplasmic staining in neoplastic endothelium. It is an excellent tool for studying tumor angiogenesis, targeted cancer therapies, and vascular differentiation.
Mouse
Recombinant human TEM8 protein
TEM8/589
IgG1, kappa
Human, Non-human Primates, Dog, and Rabbit. Others not known.
P23 cells. Colon or breast carcinoma.
This antibody recognizes a protein of ~63kDa, identified as Tumor Endothelial Marker 8 (TEM8).
Cell surface
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