Ubiquitin GM191 is a monospecific mouse monoclonal antibody engineered to recognize ubiquitin, a small but vital regulatory protein involved in tagging other proteins for degradation via the ubiquitin-proteasome system. As a monoclonal antibody, GM191 is derived from a single clone and targets a specific epitope on the ubiquitin molecule, ensuring high specificity and reproducibility across experiments. The GM191 clone is particularly valuable in detecting mono- and polyubiquitinated proteins in various cellular contexts, aiding in the study of protein turnover, cell cycle regulation, DNA repair, and stress responses. Its mouse origin makes it compatible with a wide range of detection systems and secondary antibodies commonly used in immunohistochemistry (IHC), western blotting, and immunocytochemistry. In pathology, the GM191 antibody is frequently used to identify ubiquitin-positive inclusions seen in neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Huntington's disease, helping to elucidate mechanisms of protein aggregation and cellular dysfunction. Its monospecific nature allows for consistent, high-fidelity staining, making it a reliable tool for both research and diagnostic applications.
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Brain
Cytoplasmic and membranous
IgG2a /κ
Recombinant human Ubiquitin protein fragment (around aa 1-119)
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