Product Overview
Clone: GR53479
YAP1 Rabbit Monoclonal Antibody, Clone GR53479, is a highly specific antibody designed to detect Yes-associated protein 1 (YAP1), a pivotal regulator within the Hippo signaling pathway. YAP1 functions as a transcriptional co-activator that influences genes involved in cell proliferation, apoptosis, and organ size control. It is typically localized in the cytoplasm but translocates to the nucleus when the Hippo pathway is inactive, promoting gene expression linked to growth and survival. Clone GR53479 delivers robust nuclear and cytoplasmic staining in YAP1-expressing cells and is optimized for immunohistochemistry in formalin-fixed, paraffin-embedded tissue samples. This antibody is particularly useful in cancer research and diagnostics, as overexpression or nuclear localization of YAP1 has been associated with tumor progression and poor prognosis in several malignancies. With high affinity and consistent performance, Clone GR53479 serves as a reliable tool for exploring YAP1’s role in cellular signaling, tumor biology, and therapeutic targeting.
